So you’ve got a problem: you’re sending people on a year-long voyage with no gravity, and people don’t work well without gravity.
Simple solution: you spin up your space ship and create your own gravity. Problem solved.
Except that people haven’t evolved to live in a small, spinning frame of reference, and when you raise your arms, only to have them go sideways instead, motion sickness is the least of your worries…
Watch the lab training astronauts for precisely that: